the foundational difference is where and how the engine mounts to the frame. the L6 has engine mounts that are mounted to unique perches which bolt on top of the main cross member whereas the 302 sits further back and mounts to perches riveted to the rear of the cross member and the frame rails. believe it or not, it sits back about two cylinders worth. the line where the engine meets the bell housing is exactly the same. the bell housing will fit perfectly. the flex plate WILL NOT. being that you have an L6 now are you sure of the trans? is it a c5 or an AOD? best to look at the pan which the aod will say "metric" stamped into it. and also, it will have an extra cable going to the carb for throttle valve modulation. another tell is the shift indicator on the cluster. the aod will not show a second gear setting. it will show p,r,n,od,d,l. some models show 1 in lieu of L.
as long as you keep the trans then all behind it will not change. if you change the trans then all may be affected. there are still differences to consider if going forward with a v8 swap. there are 302s and there are 5.0s. they are not the same!